CE Hours: 1.5

Seq# 90 - Is There a Local Regulation of Pulp Inflammation?

This session will be recorded and available through IADR CE On Demand after the meeting for Continuing Education Credit.  

There is compelling evidence that tissue inflammatory and regenerative processes are tightly linked via shared molecular and cellular regulatory networks.
Clinical and experimental evidence indicates a local regulation of pulp inflammation. This appears essential in the dental pulp which is extensively innervated and highly vascularized and, at the same time, located within an inextensible environment.

Recent data have reported that the local regulatory mechanisms are triggered by local pulp injury and infection. This is well illustrated by the complement system local synthesis and activation, induction of angiogenesis under hypoxia, neurotransmitters delivery by pulpal nerves and the local interaction between the immune response and the dentinogenic response.
Thus, along with infection control, the level and temporality of the inflammatory response within the tooth is key to tissue survival and regeneration. Mechanistic modulation of these two interacting processes may therefore provide new therapeutic opportunities in the future.

Learning Objectives:

  • To establish a role for neuropeptides in the local inflammatory response within the dental pulp and to identify their potential pro- and anti-inflammatory effects.
  • To consider complement system local regulation as a powerful mechanism in pulp inflammation control.
  • To understand the mechanisms of hypoxia and cell-cell contact on regulating angiogenesis and blood vessel maturation in pulp inflammation and regeneration and to understand the molecular and cellular interaction between pulp inflammation and tissue healing and how these processes could be modulated for dentine-pulp complex health and repair.