posterpresentation
Description

Title: 1643 - Vitamin D and Periodontal Disease: A Systematic Review

Authors:

Maxine Strickland (Presenter)
Rutgers School of Dental Medicine

Jennifer Kantor, Rutgers School of Dental Medicine
Adriana Creanga, Rutgers School of Dental Medicine
Steven Singer, Rutgers School of Dental Medicine

Abstract:

Objectives:
Approximately 85% of the US population is found to be deficient in vitamin D, causing a lack of the anti-inflammatory properties of this vitamin. Periodontal disease, an inflammatory process, may be more likely to develop in a population that is vitamin D deficient. The purpose of this systematic review of the literature and a meta-analysis of relevant data is to review the literature for associations between vitamin D use and prevalence and extent of periodontal disease.

Methods:
This systematic review and meta-analysis were granted IRB-exemption. In performing a systematic review, a comprehensive search of the literature was conducted. Data bases included were PubMed, Medline, Cochrane, Scopus, Tripdata base and Web of Science. Inclusion criteria were case control studies where both vitamin D use and periodontal status were recorded. A meta-analysis was performed on the data pertaining to vitamin D deficiency versus non- vitamin D deficiency and presence or absence of periodontal disease.

Results: The systematic review article synthesis yielded a total 2,212 records identified through a database search. Only 4 studies were included in the quantitative synthesis and meta-analysis. Systematic review and meta-analysis were done and the forest plot revealed that Vitamin D deficient patients were3.293 times as likely to have periodontal disease in comparison to the group that was nonvitamin D deficient (95% CI: 1.04-10.4, p=0.042). The funnel plot shows an asymmetry which may indicate possible publication bias. High heterogeneity was observed (I2=84%, p<0.001).

Conclusions: Vitamin D supplements may have a protective effect against developing periodontal disease.

Disclosure Statement:
The submitter must disclose the names of the organizations with which any author have a relationship, the nature of the relationship, and the clinical or research area involved. The following is submitted: NONE

Tags