Title: 1643 - Vitamin D and Periodontal Disease: A Systematic Review


Maxine Strickland (Presenter)
Rutgers School of Dental Medicine

Jennifer Kantor, Rutgers School of Dental Medicine
Adriana Creanga, Rutgers School of Dental Medicine
Steven Singer, Rutgers School of Dental Medicine


Approximately 85% of the US population is found to be deficient in vitamin D, causing a lack of the anti-inflammatory properties of this vitamin. Periodontal disease, an inflammatory process, may be more likely to develop in a population that is vitamin D deficient. The purpose of this systematic review of the literature and a meta-analysis of relevant data is to review the literature for associations between vitamin D use and prevalence and extent of periodontal disease.

This systematic review and meta-analysis were granted IRB-exemption. In performing a systematic review, a comprehensive search of the literature was conducted. Data bases included were PubMed, Medline, Cochrane, Scopus, Tripdata base and Web of Science. Inclusion criteria were case control studies where both vitamin D use and periodontal status were recorded. A meta-analysis was performed on the data pertaining to vitamin D deficiency versus non- vitamin D deficiency and presence or absence of periodontal disease.

Results: The systematic review article synthesis yielded a total 2,212 records identified through a database search. Only 4 studies were included in the quantitative synthesis and meta-analysis. Systematic review and meta-analysis were done and the forest plot revealed that Vitamin D deficient patients were3.293 times as likely to have periodontal disease in comparison to the group that was nonvitamin D deficient (95% CI: 1.04-10.4, p=0.042). The funnel plot shows an asymmetry which may indicate possible publication bias. High heterogeneity was observed (I2=84%, p<0.001).

Conclusions: Vitamin D supplements may have a protective effect against developing periodontal disease.

Disclosure Statement:
The submitter must disclose the names of the organizations with which any author have a relationship, the nature of the relationship, and the clinical or research area involved. The following is submitted: NONE