Title: 3120 - Craniofacial Morphology Assessment of Brazilian Sheehan Syndrome Adults: Case-control Study


Davi Cavalcante (Presenter)
Federal University of Ceará

Adília Cid, Federal University of Ceará
Francisco Carvalho, University of Fortaleza (UNIFOR)
Daniel Barbosa, Federal University of Ceará
Thyciana Rodrigues Ribeiro, Federal University do Ceara
Isabella Resende, UNICHRISTUS University Center
Paulo Goberlânio de Barros Silva, UNICHRISTUS University Center
Ana Rosa Quidute, Walter Cantidio Universitary Hospital
Fábio Costa, Federal University of Ceará


Objectives: This study aimed to perform a cephalometric evaluation of craniofacial morphology in Brazilian Sheehan Syndrome (SS) patients, which is a form of chronic hypopituitarism still considered a significant public health problem in developing countries.

Methods: Lateral cephalometric radiographs were obtained from 19 adult women diagnosed with SS at the Division of Endocrinology and Diabetology (Walter Cantídio University Hospital, Fortaleza, Brazil) and 19 age- and sex-matched controls. The skeletal cephalometric profile included angular and linear measurements traced on digital teleradiographs by using the Radiocef Studio 2 software. Mean values and standard deviations (SD) were obtained. The level of significance was set at 5%.

Results: The mean age of SS was 65.47±10.19. SS group showed: maxilla position relative to the cranial base propositioned in 52.63% (S-N-A>820); propositioned mandible in 52.63% (S-N-B>800); mandibular prognathism in 73.68% (A-N-B < 20); deep growth pattern in 42.1% (S-N/Go-Gn<320); increased mandibular plane in 36.84%; and reduced anterior facial height (N-Me <114 mm). SS group compared to controls showed statistically significant difference regarding S-N-B (p=0.026), N-Me (p=0.006), soft palate (p=0.011), and ANS-Me (p<0.001). The SD score (SDS) was abnormal in relation to total maxillar length (Co-A, SDS = 3.5±10.84) and total mandibular length (Co-Gn, SDS = 5.2±15.38).

Conclusions: In brief, SS individuals showed a craniofacial pattern characterized by maxillary/mandibular prognathism, short face, mandibular plane increased, and reduced soft palate length. Thus, this study addressed important aspects regarding craniofacial findings in SS not published to date.

Student Presenter

Disclosure Statement:
The submitter must disclose the names of the organizations with which any author have a relationship, the nature of the relationship, and the clinical or research area involved. The following is submitted: None.