Title: 1562 - DEEP Study: Modelling Persistent Orofacial Pain Management’s Costs and Benefits


Justin Durham (Presenter)
Newcastle University

Matthew Breckons, Institute of Health and Society, Newcastle University
Luke Vale, Institute of Health and Society, Newcastle University
Jing Shen, Institute of Health and Society, Newcastle University


Objectives: Persistent orofacial pain (POFP) impacts on the daily lives of patients and can lead to significant costs for them and/or the health service provider. This study aimed to examine, the costs and quality-of-health experienced by individuals with POFP and use these data to estimate these outcomes from pain onset over an individual’s life-course.

Methods: A total of 202 people receiving care for POFP both in community and specialist settings were followed for 24-months. Data were collected every six months on: health service utilisation; pain-related disability (Graded chronic pain scale [GCPS] dichotomised to low [0-IIa] or high [IIb-IV] states); and health-related quality-of-life measured by quality-adjusted life years (QALYs) derived from EQ-5D-5L. Regressions were conducted to show how costs and QALYs varied according to participant characteristics with the results used to parameterise a Markov model. A probabilistic Markov model was used to estimate the outcomes for a cohort of POFP patients from age 25 until death.

Results: Data were available at all time-points from 132 participants, and 594 and 575 observations were available to perform the regressions for costs and utilities, respectively. High GCPS state led to significantly increased healthcare cost (£207; 95%CI: 77;337; p<0.01) as well as a significant decrease in quality-of-life (Mean difference -0.71; 95%CI: -0.10; -0.04 p<0.0001). The Markov model estimated that the average cost was £24,627 (SD+/-315) and the average lifetime QALYs were 18 (SD(+/-1).

Conclusions: Given the prevalence of POFP (~7%) the lifetime costs of care are of considerable importance to the health service. A cohort of POFP patients from age 25 were assumed to all die by the age of 100 but on average would only accrue 18 QALYs per person. These data demonstrate the burden of POFP on health and illustrate the potential gains to be made from more effective care.

This abstract is based on research that was funded entirely or partially by an outside source:
This study and JD were funded by a NIHR Clinician Scientist award (NIHR-CS-011- 003). The views expressed in this publication are those of the author (s) and not necessarily those of the NHS, the National Institute for Health Research, or the Department of Health in the United Kingdom.

Disclosure Statement:
The submitter must disclose the names of the organizations with which any author have a relationship, the nature of the relationship, and the clinical or research area involved. The following is submitted: NONE