Title: 3277 - Evaluation of Multi-ion Release From Nano S-PRG Filler


Toshiyuki Nakatsuka (Presenter)

Hideto Kasaba, SHOFU Inc.
Yuuya Mimaki, SHOFU Inc.
Akihiro Nagafuji, SHOFU INC.
Kazuya Shinno, SHOFU


Objectives: Several studies have reported the bioactive effects derived from multiple ions released from trilaminar-structured S-PRG filler particles. We have recently nanosized the S-PRG filler to further enhance its functionality. This study aimed to investigate multi-ion release of nanosized S-PRG filler compared to that of submicron- and micron-sized S-PRG filler particles.

Methods: Nanosized S-PRG filler (NanoPRG; mean particle size (MPS)=0.4µm) was synthesized in conventional method (with modified grinding process). For comparison, conventionally-synthesized submicron S-PRG filler (SubPRG; MPS=0.8µm) and micron S-PRG filler (MicronPRG; MPS=3.0µm) were used. Each S-PRG filler was mixed with distilled water (MIX ROTOR, 100rpm; filler/water weight ratio=1/10; up to 24h). Each filler/water mixed liquid was collected at varied time points and filtrated (filter pore size: 0.45µm followed by 0.2µm), and concentrations of released ions (Al3+, BO33-, Na+, SiO32-, Sr2+, F- as identified in our previous study) in filtrates were quantified by ICP-AES and the fluoride ion electrode method to examine the release behavior of respective ions from each S-PRG filler.

Results: For all PRG groups, the release of the respective ions, except Al ions, increased with increasing mixing time, eventually reaching saturated levels. NanoPRG maintained the highest ion-release levels among all groups throughout the 24h mixing duration. The release of Al ions was low at early time points and remained unchanged for the rest of the duration for all groups. The release of the respective ions was in the following order for all groups: BO33->Na+>F->Sr2+>SiO32->Al3+.

Conclusions: The high level of multi-ion release from NanoPRG may be associated with specific surface area of its nanoparticles. When applied in dental materials, NanoPRG is expected to further enhance the bioactive effects due to its increased multi-ion-releasing ability. Its potential clinical utility and efficacy hold promise for contributing to providing healthy oral environment and longer tooth lifespan.


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Disclosure Statement:
The submitter must disclose the names of the organizations with which any author have a relationship, the nature of the relationship, and the clinical or research area involved. The following is submitted: NONE