Title: 3256 - Idiomatic Salivary and Blood Lead Level as Dental Caries Biomarkers
Girish Parmar (Presenter)
Government Dental College, Ahmedabad
Shantanu Choudhari, Government Dental College & Hospital
Objectives: Role of trace elements in the development of dental caries has been an area of interest since the identification of the protective effects of fluoride. Hence, lead being a significant pollutant , this study was carried out to examine the association between individual's salivary lead and blood lead levels with dental caries.
Methods: It was a cross sectional study with sample size of 100 subjects of age group 8-12 years in both study and control group. Study group was subjects with dmft/DMFT>5 and control was subjects with dmft/DMFT=0.Samples of unstimulated saliva and blood were collected from all subjects and lead estimation was done by ICP-MS method. Unpaired student t-test was used for statistical analysis, with level of significance set at 0.05.
Results: A highly significant association was found between salivary lead level and the dental caries. Blood lead level showed a positive correlation with dental caries. In either samples, the p value was found to be <0.005.Subjects with dmft/DMFT=0(control group) had a mean salivary lead level of 2.84 and a mean blood lead level of 21.81. Subjects with dmft/DMFT>5(study group) had a mean salivary lead level of 8.00 and a mean blood level of 26.68.
Conclusions: The salivary and blood lead levels were found to be higher in subjects with dental caries proving the cariogenic potential of lead. Saliva proved to be a better biomarker than blood in analyzing the lead levels. Dentist should be aware of environmental pollutants like lead that can adversely affect general and dental health. There is scope for future research to identify those mixtures of micro-minerals in food and water supplies which may exert a cariogenic effect.
The submitter must disclose the names of the organizations with which any author have a relationship, the nature of the relationship, and the clinical or research area involved. The following is submitted: NONE