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Title: 0807 - TiF4 Varnish for Treatment of Caries in Children Permanent Dentition

Authors:

Beatriz Souza (Presenter)
University of São Paulo

Daiana dos Santos, University of São Paulo
Aline Braga, University of São Paulo
Natália dos Santos, University of São Paulo
Daniela Rios, University of São Paulo
Marilia Afonso Rabelo Buzalaf, University of São Paulo
Ana Magalhães, University of São Paulo

Abstract:

Objectives: This 6-month randomized clinical trial (RTC) compared the effect of 4% TiF4 varnish with a commercial 5% NaF varnish in the treatment of noncavitated enamel carious lesions in permanent teeth of children living in a fluoridated area.

Methods: This randomized, controlled, parallel and single blind clinical trial involved 63 children, 6-7 years old, living in Bauru-SP/Brazil. Children were selected according to their caries activity (presence of at least 1 tooth with score Nyvad 1) and randomly divided into the following treatments: 4% TiF4 varnish (2.45% F-, pH 1, FGM); 5% NaF varnish (2.26% F-, pH 5, Duraphat®, Colgate) and negative control (placebo varnish, pH 5, FGM). The varnishes were applied on all permanent teeth, once a week for 4 consecutive weeks. Two calibrated examiners carried out the clinical examination (Nyvad index, kappa>0.8) at baseline, after the 1st and 6th month of the beginning of the study. Quantitative fluorescence changes were also measured using QLF device at the same periods. The degree of patient satisfaction with the treatment was also reported.

Results: Slight clinical and fluorescence changes were seen in the lesions during the period of the study. No significant differences between treatments with respect to caries lesions regression or progression (Nyvad-index) were detected after the 1st (Kruskal-Wallis/Wilcoxon, p>0.05) and the 6th month (Table 1). Also no differences between the treatments were detected with respect to the lesion area (WS) and the mean fluorescence loss (ΔF) (ANOVA/Kruskal-Wallis, p>0.05, Table 1). Regardless of the treatment, more than 75% of the participants reported to be satisfied with the treatments.

Conclusions: In conclusion, the fluoride treatments did not improve remineralization of noncavitated enamel carious lesions during 6 months of follow up. The participants will be still under follow up for a total period of 18 months, to check possible differences between the fluoride varnishes.

Table(s):

  Nyvad index Area WS (mm2) ΔF (%)
TiF4 NaF Placebo TiF4 NaF Placebo TiF4 NaF Placebo
Baseline 1.0
(0.5 to 1.0)
1.0
(0.3 to 1.0)
1.0
(0.5 to 1.0)
2.4
(1.4 to 4.8)
3.1
(0.1 to 5.6)
2.6
(1.7 to 7.2)
-16.0
(-27 to -10)
-15.3
(-22 to -8)
-15.0
(-21 to -13)
6 months 1.0
(1.0 to 2.3)
1.0
(1.0 to 1.7)
1.0
(1.0 to 1.0)
2.9
(1.6 to 5.7)
3.1
(1.9 to 6.5)
2.5
(1.4 to 4.8)
-15.3
(-21 to -12)
-16.9
(-20 to -10)
-13.9
(-17 to -12)

This abstract is based on research that was funded entirely or partially by an outside source:
FAPESP (2015/14149-1) and CNPq (401313/2016-6)

Disclosure Statement:
The submitter must disclose the names of the organizations with which any author have a relationship, the nature of the relationship, and the clinical or research area involved. The following is submitted: NONE

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