Title: 1304 - Nutrition Contributes to the Relationship Between Tooth Loss and Mortality
Takako Hiratsuka (Presenter)
Takamasa Komiyama, Tohoku University
Takashi ohi, Tohoku University
Akito Tsuboi, Tohoku University
Fumiya Tanji, Tohoku University Graduate School of Medicine
Yasutake Tomata, Tohoku University Graduate School of Medicine
Ichiro Tsuji, Tohoku University Graduate School of Medicine
Makoto Watanabe, Tohoku Fukushi University
Yoshinori Hattori, Tohoku University
Objectives: A growing number of epidemiological studies have shown the association between tooth loss and mortality. Nutritional status and systemic inflammation are reported to be potential contributors to the relationship between tooth loss and mortality. The purpose of this study was to examine whether nutritional status or systemic inflammation contributed to the association between tooth loss and mortality in elderly community-dwelling Japanese adults.
Methods: This prospective cohort study targeted community-dwelling adults aged ≥ 70 years (N = 891) in Japan. The number of remaining teeth was counted by specially trained dentists. Participants were divided into four groups according to their number of remaining teeth (edentulous, 1–9 teeth, 10–19 teeth, ≥ 20 teeth). Nutritional status and systemic inflammation were evaluated using serum albumin level and high-sensitivity C-reactive protein level, respectively. The outcome variable was all-cause mortality from survey baseline in 2003 to 2016. The Cox proportional hazard model was used to estimate hazard ratios (HRs) for the association between the number of remaining teeth and mortality, and the contributions of nutrition status and systemic inflammation. Covariates were age, sex, smoking, alcohol consumption, medical history, duration of education, depressive symptoms, cognitive impairment, and physical function.
Results: 317 participants died during a follow-up period of 9620 person-years. In the adjusted model, the hazard ratios for mortality were significantly higher for edentulous participants (HR: 1.83, 95% confidence interval [CI]: 1.30–2.57) and those with 1–9 teeth (HR: 1.76, 95%CI: 1.28–2.41) than for those with ≥ 20 teeth. Mediation analyses showed that nutritional status contributed to increased HRs in edentulous individuals, those with 1–9 teeth, and participants with 10–19 teeth, but systemic inflammation was not a contributing factor.
Conclusions: These findings suggested that tooth loss was associated with mortality through changes in nutritional status in community-dwelling elderly population.
The submitter must disclose the names of the organizations with which any author have a relationship, the nature of the relationship, and the clinical or research area involved. The following is submitted: NONE