Title: 0388 - Craniofacial Skeletal Phenotype in Obstructive Sleep Apnoea-hypopnoea: A Systematic Review and Meta-analysis


Bahn Agha (Presenter)
Queen Mary University of London

Ama Johal, Queen Mary University of London


Objectives: This systematic review & meta-analysis explores the association between skeletal phenotype and obstructive sleep apnoea-hypopnea syndrome in adults.

Methods: A comprehensive electronic database [Medline via Ovid, Scopus, Web of science, ProQuest Dissertation and Thesis database and Embase), Google Scholar and reference search were undertaken. The outcome measures were cephalometric findings of craniofacial skeletal morphology for sleep apnoea subjects and controls. The quality of studies was assessed and a meta-analysis conducted.

Results: This systematic review identified 63 case-control studies. The pooled results demonstrated adults with obstructive sleep apnoea showed significant weighted mean differences in a range of antero-posterior, vertical skeletal parameters and hyoid position than controls, with very little ethnic variations being apparent. In 12 Caucasian studies (1477 participants), adults with sleep apnoea showed a significant weighted mean difference in cranial base angle by -1.44 degree (P=0.00001) with no heterogeneity between studies (I-square=0%). The same degree of variation presented in the Oriental group -1.79 degree (P= 0.001,I-square= 0%). Significant weighted mean differences with moderate heterogeneity were found in Caucasian and Oriental groups for the following parameters respectively: cranial base length (SN: -2.59, -2.04 mm); bony nasopharynx length (Ba-PNS: -3.14, -2.80 mm); mandible (SNB: -0.95°, -1.10°; Go-Me: -3.88, -3.58 mm).

Conclusions: In conclusion, skeletal assessment was able to demonstrate some characteristic morphological features, facilitating a meta-analysis, in adults with obstructive sleep apnoea-hypopnea syndrome. The strength of these findings is improved by the low to moderate heterogeneity, permitting the identification of a clear phenotype.

Student Presenter

Disclosure Statement:
The submitter must disclose the names of the organizations with which any author have a relationship, the nature of the relationship, and the clinical or research area involved. The following is submitted: NONE