Title: 0143 - Effects of Number of Micro-osteopeforations (MOPs) on Rate of OTM


Edmund Khoo (Presenter)
New York University

Bandar Alyami, CTOR
Salem Al-moammar, CTOR


Objectives: To study the effect of number of MOPs on the rate of orthodontic tooth movement (OTM) and expression of inflammatory markers in humans.

Methods: After IRB approval, 30 adults with class II, division I malocclusion that fit the inclusion criteria were divided into control and experimental groups with one perforation or 5 perforations. All groups were monitored for oral hygiene and treated with similar mechanics. The Control group did not received MOPs while the Experimental group received MOPs only in one side at the beginning of canine retraction. Canines were retracted bodily by applying a force closer to center of resistance. The rate of canine retraction was measured for 28 days. Activity of different inflammatory markers was measured in gingival crevicular fluid at different time points using antibody-based assays. Pain and discomfort was monitored using a numerical rating scale.

Results: 5 MOPs significantly increased the rate of tooth movement. This increase was accompanied with significant increase in the activity of inflammatory markers CCL-2, CCL3 and CCL5, IL-1, TNF-a and IL-6 in a time-dependent manner. Patients did not report significant pain or discomfort during or after procedure.

Conclusions: Number of MOPs play a significant role on rate of tooth movement during orthodontic tooth movement.

Disclosure Statement:
The submitter must disclose the names of the organizations with which any author have a relationship, the nature of the relationship, and the clinical or research area involved. The following is submitted: NONE