Title: 0358 - The Effect of Bioactive Glass Blasting on Titanium Implant Coatings
Farah Al-Khayyat (Presenter)
Queen Mary University of London
Robert Hill, QMUL
Natalia Karpukhina, Barts and The London School of Medicine and Dentistry
Simon Rawlinson, Barts and The London School of Medicine and Dentistry
Objectives: The survival rate of dental implants depends on successful osseointegration. Physical and chemical modifications to the implant surface are attractive routes for enhancing osseointegration. Abrading the surface and embedding bioactive glasses into the implant could improve the extent of osseointegration. The aim is to develop a bioactive and biocompatible glass that enhances the implant surface roughness and biological properties by embedding particles into the surface.
Methods: Titanium disks of 10 mm diameter and 1 mm thickness were prepared from commercially pure titanium sheet. The disks were polished to a mirror surface and then abraded with sodium containing bioactive glasses of varied hardness and particle size (63-90 µm) using grit blast technique. The samples were examined by white light profilometry for abraded line width, depth, volume loss and surface roughness, and by Scanning Electron Microscopy (SEM) for determining the surface coverage. The cell differentiation (Alkaline Phosphatase ALP activity) and mineralization (Alizarin Red S stain) on both titanium and glass-abraded disks were studied.
Results: The glass particles were abrasive enough to significantly increase the surface roughness of the titanium samples from Ra 0.1 μm to Ra 1.6 μm (P>0.05). The percentage of the area coverage by the glasses was in the range between 52–62 %. Changing the abrasion parameters and glass composition effected the abraded line depth and volume removal. As the hardness of the glass increased, then more of it embedded into the surface. The ALP activity and mineralization of the osteoblasts were higher on the glass surface compared with titanium surface.
Conclusions: Biocompatible glasses are evenly distributed and successfully embedded into the titanium surface. Therefore, grit blasting with the chosen glasses appears to be a promising coating procedure for dental implants.
The submitter must disclose the names of the organizations with which any author have a relationship, the nature of the relationship, and the clinical or research area involved. The following is submitted: none