Title: 0120 - A Versatile Poly(methyl methacrylate) Cement Functionalized With Quaternized Chitosan-glycerophosphate/hydroxyapatite Hydrogels
Yue Sa (Presenter)
School & Hospital of Stomatology, Wuhan University, PR China
Man Wang, School & Hospital of Stomatology, Wuhan University, PR China
Tao Jiang, School & Hospital of Stomatology, Wuhan University, PR China
Yining Wang, School & Hospital of Stomatology, Wuhan University, PR China
Objectives: To design a more versatile version of PMMA cement with adorable properties to target drawbacks for future clinical application
Methods: We synthesized a modified version by combining PMMA with quaternized chitosan (N-(2-hydroxy)propyl-3-trimethylammonium chitosan chloride, HTCC)-based hydrogels loaded with nanosized hydroxyapatite (Nano-HA). Then, the physicochemical properties, antimicrobial properties, remineralization capacity and mechanical performance changes under imitated physiological conditions were tested for these cements using a type K thermocouple, scanning electron microscope (SEM), microcomputed tomography (µ-CT), calcium ion test kit and mechanical compression tests.
Results: The results showed that the HTCC-GP thermosensitive hydrogel lowered the Tmax value, lengthened the working time, generated interconnected pores, developed appropriate mechanical properties and imparted excellent antibacterial activity to the cement. The Nano-HA particles engendered improved biomineralization ability of the cements without adversely influencing the mechanical performance.
Conclusions: Results indicated that the injectable and multifunctional cement resulting from the p-PMMA/HTCC-GP/Nano-HA combination holds strong promise for future bone reconstruction applications.
This abstract is based on research that was funded entirely or partially by an outside source:
This work was supported by the National Natural Science Foundation of China (No. 81500887).
The submitter must disclose the names of the organizations with which any author have a relationship, the nature of the relationship, and the clinical or research area involved. The following is submitted: NONE