oralpresentation
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Title: 0119 - Kinetic Barrier Membrane Performance of Two Standard Collagen Membranes

Authors:

Fabien Bornert (Presenter)
University of Strasbourg

Rebecca Sandgren, Lund University, Biomedical Center
Benjamin Bellón, Institut Straumann AG
Benjamin Pippenger, Institut Straumann AG
Shakeel Shahdad, Queen Mary University of London

Abstract:

Objectives: The objective of the present study was to show that a porcine pericardium collagen membrane (botiss Jason® membrane) applied to a bone substitute-grafted defect is suitable to inhibit soft tissue ingrowth for at least 3 months.

Methods: 18 adult male Yucatan minipigs with age of 20 - 24 months were included in the study. Lower premolars P2, P3, P4 and first molar M1 were extracted bilaterally. Following 4 month of healing 4 semi-saddle bone defects were created per mandible, filled with two bovine xenografts respectively (BioOss® or Cerabone®) and covered with the respective collagen membranes (Bio-Gide® or Jason®). The 18 operated animals were sacrificed and split into 3 groups : 6 animals per time point at 4, 8 and 12 weeks of healing. The mandibles were retrieved for histological processing. Microscopic observation and measurements of the residual membrane across the buccopalatal cross-section of the defects were done.

Results: Histologic micrographs of experimental groups revealed residual membrane presence at all time points in vivo. Ranked residual membrane as a function of time demonstrated significant degradation after 12 weeks in vivo relative to 4 weeks (p = 0.017), without significant difference between 4 and 8 weeks (p = 0.147). Data as a function of experimental groups depicted absence of significant difference between membrane types irrespective grafting material (p > 0.093).

Conclusions: The examined porcine pericardium collagen membrane is statistically non-inferior to the control collagen membrane in terms of barrier function and resorption kinetics. The barrier function remained intact up to 12 weeks in vivo in the present model. These data suggest that the examined pericardium membrane begins to undergo significant degradation between 8 and 12 weeks, which appears to be sufficient to allow a concerted bone healing process to occur

This abstract is based on research that was funded entirely or partially by an outside source:
This study was funded by Institut Straumann AG.

Disclosure Statement:
The submitter must disclose the names of the organizations with which any author have a relationship, the nature of the relationship, and the clinical or research area involved. The following is submitted: This study was funded by Institut Straumann AG. Benjamin Pippenger and Benjamin Bellón are employed by Institut Straumann AG.

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