Title: 0579 - Bioactive Properties of a Novel Basic Restorative Material


Benjamin Gebhardt (Presenter)
Ivoclar Vivadent

Nino Haller, Ivoclar Vivadent
Urs Lendemann, Ivoclar Vivadent
Ronny Schumacher, Ivoclar Vivadent
Thorsten Bock, Ivoclar Vivadent


Objectives: As robust and easy-to-use basic restorative materials are becoming common, bioactivity is gaining importance.[1, 2] One aspect of bioactivity is related to ion release, providing remineralization effects or acid neutralization. Here, the bioactive properties as remineralization and acid neutralization potential of a novel basic restorative material for amalgam replacement (Cention N) are evaluated.

Methods: Different methods were used to investigate effects of ion release on the surrounding tooth substrate. The calcium (Ca2+) and fluoride (F-) release from Cention N was quantified using atomic absorption spectroscopy (AAS) and ion-selective electrode (ISE) analysis. The release of hydroxid ions (OH-) was detected using micro pH-electrodes placed in model cavities. Formation of inorganic precipitates after storage in artificial saliva was assessed by scanning electron microscopy (SEM) and the precipitates' elemental composition determined by energy-dispersive x-ray spectroscopy (EDX). Remineralization potential of Cention N was determined on bovine enamel adjacent to restorations after simulated caries attack using micro hardness measurements and dye penetration tests. References samples with an ion releasing glass ionomer cement (GIC) Fuji IX (GC) and a non-ion releasing composite Tetric N-Ceram (Ivoclar Vivadent).

Results: The release of Ca2+ and F- from Cention N was detectable over 3 years in neutral and acidic buffer solution. SEM and EDX analysis after 1-month in artificial saliva showed a 0.5 μm thick layer of inorganic precipitates consisting of calcium, fluoride and phosphate. Using micro pH-electrodes in model cavities, the release of OH- was shown to cause an alkaline pH of 8-9. Enamel next to Cention N and GIC restorations showed significantly higher micro hardness values compared to enamel next to non-ion releasing composite. Similarly, no dye penetration into acid-challenged enamel was detected next to Cention N and GIC restorations, whereas enamel was dye penetrated next to the non-ion releasing composite restoration.

Conclusions: Long-term ion release from Cention N (Ca2+, F- and OH-) was verified using several methods. The ion release resulted in the formation of calcium, fluoride and phosphate precipitates in presence of artificial saliva. Cention N neutralized acidic pH in model cavities.


Download Image 1
Download Image 2

Disclosure Statement:
The submitter must disclose the names of the organizations with which any author have a relationship, the nature of the relationship, and the clinical or research area involved. The following is submitted: All authors are co-workers from Ivoclar Vivadent