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Description

Title: 0343 - Antibacterial Glass Ionomer Cement With Chlorhexidine-Encapsulated Mesoporous Silica

Authors:

Huiyi Yan (Presenter)
The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory for Oral Biomedical Ministry of Education, School & Hospital of Stomatology, Wuhan University

Hongye Yang, The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory for Oral Biomedical Ministry of Education, School & Hospital of Stomatology, Wuhan University
Cui Huang, The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory for Oral Biomedical Ministry of Education, School & Hospital of Stomatology, Wuhan University

Abstract:

Objectives: This study aims to (1) establish a CHX (Chlorhexidine) delivery system based on expanded-pore mesoporous silica (CHX@pMSN), (2) develop a new strategy that endows GIC (Glass Ionomer Cement) with anti-biofilm ability by appropriate addition of CHX@pMSN, and (3) evaluate the effects of CHX@pMSN on the mechanical properties of the modified GIC.

Methods: pMSN was synthesized and then CHX was encapsulated to synthesize CHX@pMSN. These two materials were examined using TEM. The average weight percentage of CHX on pMSN was analyzed through TGA. CHX@pMSN was added at three mass fractions (1%, 5%, and 10% (w/w)) to GIC powder as the experimental groups. Pure GIC was set as the control group. The mechanical and anti-biofilm of S. mutans properties of GIC from each group were tested via MTT assay, FESEM observation and CLSM observation. The mechanical properties (compressive strength, surface hardness, elastic modulus, water sorption, and solubility) and cumulative release of CHX from each group were also tested.

Results: The results demonstrated that CHX was successfully encapsuled on/into pMSN, and the encapsulating efficiency of CHX was 44.62% in CHX@pMSN. The anti-biofilm ability was significantly enhanced in all experimental groups (P<0.001) compared with that in the control group. CHX was continuously released, and anti-biofilm ability was maintained up to 30 days. In addition, the mechanical properties (compressive strength, surface hardness, elastic modulus, water sorption, and solubility) of 1% (w/w) group were maintained compared with those in the control group (P>0.05).

Conclusions: Adding 1% (w/w) CHX@pMSN to GIC led to conspicuous anti-biofilm ability and had no adverse effect on the mechanical properties of this dental restorative material. This study proposes a new strategy for preventing secondary caries by using CHX@pMSN-modified GIC.

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This abstract is based on research that was funded entirely or partially by an outside source:
the National Natural Science Foundation of China (No. 81701012 ).

Disclosure Statement:
The submitter must disclose the names of the organizations with which any author have a relationship, the nature of the relationship, and the clinical or research area involved. The following is submitted: NONE

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