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Title: 0336 - Evaluation of Anti-erosive Potential of Fluoride and Film-forming Polymers Solutions

Authors:

Daniele Ávila, UNESP - Sao Paulo State University
Rayssa Zanatta, UNESP - Sao Paulo State University
Marina Augusto, UNESP - Sao Paulo State University
Tais Scaramucci, University of Sao Paulo
Idalina Aoki, University of Sao Paulo
Carlos Torres, UNESP - Sao Paulo State University
Alessandra Borges (Presenter)
UNESP - Sao Paulo State University

Abstract:

Objectives: Formulations of mouthwashes associating film-forming polymers with fluoride represent a promising alternative to control tooth erosion. Thus, the objective of this study was to evaluate the anti-erosive potential of solutions containing two bioadhesive polymers (Carbopol-C and Propyleneglycol-PPG) associated to fluoride or fluoride plus tin [sodium fluoride-NaF (500ppm F) or NaF+stannous chloride-NaF/Sn (800ppm Sn)].

Methods: In phase I, hydroxyapatite crystals were pre-treated with solutions containing the polymers alone or their combination with fluoride or fluoride and tin. Deionized water (W) was the negative control and a commercial solution [Elmex (E) – GABA], the positive control. The pH-stat method was used to evaluate hydroxyapatite dissolution. In phase II, associations of the polymers with fluoride were tested in the presence of acquired pellicle. Enamel specimens (n=15/group) were submitted to an erosion/remineralization cycle consisting of immersion in human saliva (2h) for pellicle formation, demineralization (0.3% citric acid pH2.6 – 2 min), saliva (2h), treatment with the solutions (2 min), saliva (2h), and second demineralization. The solution's protective effect against initial erosion was investigated by Knoop microhardness (KHN). Data were analyzed by ANOVA and Tukey tests (5%).

Results: In phase I, the combination of polymers with fluoride compounds caused higher reduction in hydroxyapatite dissolution (C/PPG+NaF/Sn- 3.53±0.35mg, C/PPG+NaF- 4.24±0.36mg), compared to W (25.31±0.41mg) and Elmex (5.76±0.42). The fluoridated solutions showed intermediate values. In phase II, the KHN means were: (C/PPG+NaF/Sn- 302.3±16.6) > (NaF/Sn- 268.4±22.6) = (E- 266.6±29.1) > (C/PPG+NaF- 261.2±28.1) = (NaF- 250.4±21.9) > (W- 220.2±17.8).

Conclusions: All tested solutions exhibited an anti-erosive effect. The association of Carbopol and Propyleneglycol can improve NaF/Sn protection against enamel erosion.

This abstract is based on research that was funded entirely or partially by an outside source:
FAPESP #2015/19585-4 and #2017/13799-8

Disclosure Statement:
The submitter must disclose the names of the organizations with which any author have a relationship, the nature of the relationship, and the clinical or research area involved. The following is submitted: None

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