Title: 0455 - Effectiveness of S-PRG Filler-containing Toothpaste in Inhibiting Tooth Surface Demineralization


Bennett Amaechi (Presenter)
University of Texas Health Science Center at San Antonio

Deepika Joshi, University of Texas Health Science Center at San Antonio
Azadeh Abdollahi, University of Texas Health Science Center at San Antonio
Parveez Ahamed Abdul Azees, University of Texas Health Science Center at San Antonio


Objectives: There is need for other strategies that could work either better than or synergistically with fluoride in controlling dental caries in high risk individuals. Using an established pH cycling caries model, the authors evaluated the effectiveness of toothpastes containing surface pre-reacted glass-ionomer filler (S-PRG) in preventing tooth surface demineralization, comparing it with a standard fluoride dentifrice containing 1100 ppm fluoride as sodium fluoride (NaF).

Methods: 210 tooth blocks were randomly assigned to seven experimental groups (30 blocks/group): no treatment (A), and toothpaste containing either NaF (B), 0 wt% S-PRG (C), 1 wt% S-PRG (D), 5 wt% S-PRG (E), 20 wt% S-PRG (F) or 30 wt% S-PRG (G). The seven groups were subjected to 7-day demineralization for development of early caries lesions using a pH cycling caries model. Demineralization was assessed using Quantitative Light-induced fluorescence (QLF) and Transverse Microradiography (TMR). All pairwise contrasts (between treatments) were tested using ANOVA, and then Tukey’s HSD for multiple comparisons. All p-value are considered significant if <0.05.

Results: With QLF, there was a significant (ANOVA; p<0.001) difference in mean fluorescence loss (△F) observed among the groups. Relative to control, all S-PRG-containing toothpastes significantly (Tukey’s; p<0.0001) inhibited demineralization at varying percentages (48.6%, 61.3%, 67.4% and 69.8% reduction with S-PRG 1%, 5%, 20% and 30% respectively). Demineralization reduction was not significant with toothpastes containing either NaF (15.6% reduction) or 0% S-PRG (-2.5% reduction) when compared to control group. The mineral loss assessed using TMR followed almost similar trend as the fluorescence loss.

Conclusions: The present study demonstrated the effectiveness of toothpaste containing S-PRG filler in inhibiting tooth demineralization; thus highlighting its potential as an effective caries control tool. The study further demonstrated S-PRG filler-containing dentifrice to be more effective in preventing tooth surface demineralization than 1100 ppm fluoride provided as sodium fluoride.

Disclosure Statement:
The submitter must disclose the names of the organizations with which any author have a relationship, the nature of the relationship, and the clinical or research area involved. The following is submitted: None