Title: 0328 - High-risk Human Papillomavirus-related Oropharyngeal Cancer Among Indigenous and General Population


Xiangqun Ju (Presenter)
The University of Adelaide

Karen Canfell, Cancer Council of NSW
Megan Smith, Cancer Council of NSW
Lisa Jamieson, The University of Adelaide


Objectives: To estimate the prevalence of high-risk human papillomavirus (HR-HPV) infection, the incidence of oropharyngeal cancer (OPC) and the proportion of OPC related to HR-HPV among Indigenous populations; and to compare these with results in the general population.

PubMed, PubMed Central, Embase and MEDLINE were searched from Jan 2000 until Jan 2018 for this systematic review. We applied the following inclusion criteria: minimum of 100 cases, and relevant HR-HPV type including at least one of 16, 18, 31, 33, 35, 45, 51, 52, 56, 58, 59, 68, and 70. Data were abstracted from each study, and a meta-analysis performed to calculate the prevalence of HR-HPV infection, the incidence of OPC among Indigenous people, and the proportion of HR-HPV-related OPC population.

Results: We identified 144 studies from 3002 papers: 6/27 HR-HPV infection, 3/13 OPC among Indigenous populations, 7/21 population-based and 11/83 hospital-based HR-HPV-related OPC studies fulfilled inclusion criteria for meta-analyses. No data were identified for oral HR-HPV prevalence in Indigenous populations. The prevalence of genital HR-HPV infection among Indigenous people was 30% (95%CI: 28%-33%, I2=64.66%; p=0.01), compared with average 11.7% (range 3.3% - 48.8%) genital HR-HPV infection, and average 5.2% (range 1.4% - 27.5 %) oral HR-HPV infection worldwide. The incidence rate of OPC among Indigenous persons ranged from 0.49 to 2.85 per 100,000, compared with 0.74 to 3.72 per 100,000 among general populations. The proportion of HR-HPV-related OPC was 61% (95%CI: 57%-65%, I2=73.06%; p=0.0001) and 67% (95%CI: 61%-73%, I2=88.51%; p<0.0001) based on population and hospital studies, respectively. However, limited information on oral HR-HPV infection, and HR-HPV-associated OPC among Indigenous populations was reported.

The prevalence of HR-HPV infection among Indigenous people was higher than that in the general population. Although the proportion of HR-HPV-related OPC was higher in hospital-based studies, there were no substantial differences between population-based and hospital-based studies.

This abstract is based on research that was funded entirely or partially by an outside source:
NHMRC 1120215

Disclosure Statement:
The submitter must disclose the names of the organizations with which any author have a relationship, the nature of the relationship, and the clinical or research area involved. The following is submitted: NONE