Title: 0450 - Associations Between Edentulousness and Mortality Among English Older Adults
Anja Heilmann (Presenter)
University College London
Georgios Tsakos, University College London
Richard Watt, UCL
Panayotes Demakakos, University College London
Objectives: Evidence suggests an association between tooth loss and mortality, however residual confounding, non-representativeness of samples and short follow-up periods are limitations in most previous studies. We aimed to investigate associations between edentulousness and mortality in a representative sample of older adults in England while controlling for a wide range of potential confounders.
Methods: Participants were 8,956 individuals from the English Longitudinal Study of Ageing (ELSA), a prospective observational study of community-dwelling older people aged ≥50 years born before March 1952 and living in England. Baseline data were collected in 1999/2001. Death registrations up to February 2013 were obtained from the Office for National Statistics and linked with ELSA data. Edentulousness was measured at baseline via self-reports. Cox proportional hazard regression was used to estimate risk (hazard ratios; HR) of all-cause and cause-specific (cardiovascular and cancer) mortality by edentulousness, stratified by age group (50-64 years; ≥65 years) and sex, and adjusted for potential confounders (age, marital status, educational attainment, occupational class, smoking, alcohol, BMI and mental health measured via the GHQ-12 questionnaire).
Results: We observed 2,381 deaths over a mean follow-up period of 10.7 years. In fully adjusted models, edentate women aged 50-64 years had significantly higher risk of all-cause (HR= 2.22; 95%CI: 1.58-3.13), cardiovascular (HR=2.56, 95%CI: 1.22-5.39) and cancer mortality (HR= 2.02; 95%CI: 1.26-3.24) compared to women with natural teeth in the same age group. Edentate women aged ≥65 years had higher risk of all-cause (HR=1.17, 95%CI: 1.01-1.34) and cancer (HR=1.42, 95%CI: 1.05-1.92) but not cardiovascular mortality. Edentate men in the younger age group had an increased risk of cardiovascular mortality (HR=1.87, 95%CI: 1.04-3.38), and edentate men in the older age group had an elevated risk of all-cause mortality (HR=1.21, 95%CI: 1.06-1.40) only.
Conclusions: Edentulousness was an independent predictor of all-cause and cause-specific mortality especially among older women in England.
The submitter must disclose the names of the organizations with which any author have a relationship, the nature of the relationship, and the clinical or research area involved. The following is submitted: NONE