CE Hours: 1.5

Seq# 61 - Environmental and Antibiotic Stress on Oral Bacteria: A Target for New Therapies

This session will be recorded and available through IADR CE On Demand after the meeting for Continuing Education Credit.  

Environmental and antibiotic stress are important factors in regulating bacterial gene expression and can lead to behavioral changes linked to pathogenicity and antimicrobial resistance, an increasingly urgent threat to society. While, for many years, the inhibitory and bactericidal effects of antibiotics and other stressors were the main targets of investigative studies, the scientific community has been gradually widening its approach to also address the effects of antibiotics and other environmental stressors on microbial physiology and behavior. As such, it is essential to comprehend the microbiome changes at a community level following stressors such as antibiotic treatment (Speaker 1 - Prof. Egija Zaura). However, the impact is not only seen with regards to bacterial composition as such stimuli also affect bacterial group behavior (Speaker 2 - Prof. Fernanda C. Petersen) and individual persistence and stress tolerance (Speaker 3 - Prof. José A. Lemos). Fundamentally, the understanding of genetics and environmental factors linked to behavioral changes in bacteria is crucial to the development of new ecological treatment strategies to reestablish symbiosis (Speaker 4 - Prof. Justin Merritt). The oral cavity presents one of the most diverse microbiomes in the human body second only to the gut, and studies in oral bacteria are contributing to a better understanding of the effects of environmental stress on microbial single-cell physiology, group behavior, and community adaptation. Such knowledge gain is essential to pave new ways for the development of novel strategies to prevent and treat bacterial infections.

Learning Objectives:

  • Provision of new insights into microbial pathogenicity and the effects of antibiotics on oral microorganisms.
  • Understanding the impact of environmental stressors on microbial physiology and behavior.
  • Revealing options for alternative strategies to prevent and treat infections that circumvent unwanted effects of antibiotic therapy.